DNP-810 Topic 8 DQ 1

Grand Canyon University DNP-810 Topic 8 DQ 1-Step-By-Step Guide

This guide will demonstrate how to complete the Grand Canyon University DNP-810 Topic 8 DQ 1 assignment based on general principles of academic writing. Here, we will show you the A, B, Cs of completing an academic paper, irrespective of the instructions. After guiding you through what to do, the guide will leave one or two sample essays at the end to highlight the various sections discussed below.

How to Research and Prepare for DNP-810 Topic 8 DQ 1                       

Whether one passes or fails an academic assignment such as the Grand Canyon University DNP-810 Topic 8 DQ 1 depends on the preparation done beforehand. The first thing to do once you receive an assignment is to quickly skim through the requirements. Once that is done, start going through the instructions one by one to clearly understand what the instructor wants. The most important thing here is to understand the required format—whether it is APA, MLA, Chicago, etc.

After understanding the requirements of the paper, the next phase is to gather relevant materials. The first place to start the research process is the weekly resources. Go through the resources provided in the instructions to determine which ones fit the assignment. After reviewing the provided resources, use the university library to search for additional resources. After gathering sufficient and necessary resources, you are now ready to start drafting your paper.

How to Write the Introduction for DNP-810 Topic 8 DQ 1                       

The introduction for the Grand Canyon University DNP-810 Topic 8 DQ 1 is where you tell the instructor what your paper will encompass. In three to four statements, highlight the important points that will form the basis of your paper. Here, you can include statistics to show the importance of the topic you will be discussing. At the end of the introduction, write a clear purpose statement outlining what exactly will be contained in the paper. This statement will start with “The purpose of this paper…” and then proceed to outline the various sections of the instructions.

How to Write the Body for DNP-810 Topic 8 DQ 1                       

After the introduction, move into the main part of the DNP-810 Topic 8 DQ 1  assignment, which is the body. Given that the paper you will be writing is not experimental, the way you organize the headings and subheadings of your paper is critically important. In some cases, you might have to use more subheadings to properly organize the assignment. The organization will depend on the rubric provided. Carefully examine the rubric, as it will contain all the detailed requirements of the assignment. Sometimes, the rubric will have information that the normal instructions lack.

Another important factor to consider at this point is how to do citations. In-text citations are fundamental as they support the arguments and points you make in the paper. At this point, the resources gathered at the beginning will come in handy. Integrating the ideas of the authors with your own will ensure that you produce a comprehensive paper. Also, follow the given citation format. In most cases, APA 7 is the preferred format for nursing assignments.

How to Write the Conclusion for DNP-810 Topic 8 DQ 1                       

After completing the main sections, write the conclusion of your paper. The conclusion is a summary of the main points you made in your paper. However, you need to rewrite the points and not simply copy and paste them. By restating the points from each subheading, you will provide a nuanced overview of the assignment to the reader.

How to Format the References List for DNP-810 Topic 8 DQ 1                       

The very last part of your paper involves listing the sources used in your paper. These sources should be listed in alphabetical order and double-spaced. Additionally, use a hanging indent for each source that appears in this list. Lastly, only the sources cited within the body of the paper should appear here.

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Sample Answer for DNP-810 Topic 8 DQ 1 Included After Question

Choose a news story, published within last 2 years, about genetic or genomic technology. What is the issue presented? From the perspective of an RN or APRN, what are the ethical, cultural, religious, legal, fiscal, and societal implications of the issue? Explain. Support your rationale with a minimum of two scholarly sources.

A Sample Answer For the Assignment: DNP-810 Topic 8 DQ 1

Title:  DNP-810 Topic 8 DQ 1

Knowledge is the basis of understanding and in nursing the foundation of practice. Genomics is defined as the study of all the genes in the human genome together, including their interactions with each other, the environment, and the influence of other psychosocial and cultural factors. Genetics and genomics includes understanding the implications of its significance in patient’s lives, thus the meaning of genomics in health is a critical aspect of nursing practice. Understanding the genetic component of diseases requires knowledge of fundamental genetic science. It is critical that nurses understand the ethical, legal and social implications that arise when genomics becomes part of health care practice. Nursing is a practice discipline and so it is by actions that nurses manifest their professionalism. It requires an awareness and appreciation for the complexities and uniqueness of genetic information. Nurses must act with the greatest sensitivity and discretion in managing genetic information and privacy and confidentiality are always important in health care it is difficult to overstate their importance relative to genetic information of a patient. Protecting the privacy and confidentiality of patient information is the role of the nurse in obtaining informed consent for any procedure that requires the collection and analyzing of an individual’s DNA. 

Down Syndrome (DS) is caused by a complete or segmental triplication of human chromosome 21 (HSA21) and is the most frequent genetic cause of intellectual disability. People with DS present with developmental abnormalities and has systemic alterations in the peripheral system, as well as neurological and cognitive deficits. In 2020, the National Institutes of Health (NIH) announced that they would update their DS research plan and requested input from the research and the non-profit/family advocacy communities. Inglis et al. have distributed a questionnaire to members of the Lower Mainland Down Syndrome Society in British Columbia, Canada. It was completed by 101 parents. 41% responded that they would biologically treat their child of DS if it were possible. 27% said they would not biologically treat their child, and 32% were unsure. The major motivation for a treatment was to increase the child’s autonomy. Society’s interaction with these persons could change and that might make a whole lot of difference.

Educate patients/ families about genetics, provide with credible accurate and appropriate genetic and genomic information resources to facilitate decision making. Advocate for clients access to desired genetic/genomic services and/or resources including support groups. Advocate for the rights of all clients for autonomous, informed genetic and genomic-related decision making and voluntary action. Recognize and acknowledge the role of genomics as an integral component in the promotion of the public’s health and wellbeing. Advocate and promote the right of the individual or family to voluntarily choose or to not choose to seek genomic healthcare services. Nurses have entered the post-genomic age as professionals expected to engage with the public and provide informed up-to-date genetic information and competencies. 

References:

Inglis A, Lohn Z, Austin JC, et al. A “cure” for Down syndrome: what do parents want? Clin Genet. 2014;86:310–317. 

Petersen M.E., O’Bryant S.E. Blood-based biomarkers for Down syndrome and Alzheimer’s disease: A systematic review. Dev. Neurobiol. 2020;79:699–710. doi: 10.1002/dneu.22714. 

Riggan KA, Niquist C, Michie M, et al. Evaluating the risks and benefits of genetic and pharmacologic interventions for Down Syndrome: Views of parents. Am J Intellect Dev Disabil. 2020;125:1–13.  Yu P.K., Jayawardena A.D.L., Ba M.S., Pulsifer M.B., Grieco J.A., Abbeduto L., Dedhia R.C., Soose R.J., Tobey A., Raol N., et al. Redefining Success by Focusing on Failures After Pediatric Hypoglossal Stimulation in Down Syndrome. Laryngoscope. 2021;131:1663–1669. doi: 10.1002/lary

A Sample Answer 2 For the Assignment: DNP-810 Topic 8 DQ 1

Title:  DNP-810 Topic 8 DQ 1

Genetic technology advances have a significant clinical impact and signify that genetic testing perceptions must change. Genomic testing brings a more significant diagnostic opportunity for diagnosis alongside providing substantial predictions regarding future diagnoses. However, should therein reside an increased chance of uncertain or unexpected findings, many of which may impact multiple members of a person’s family (Zhang et al., 2015). The availability of treatment options regarding genetic technology is shifting and evolving, implicative of previously untreated disorders. Furthermore, the point of access to testing is changing with increasing provision direct to the consumer outside the formal healthcare setting (Zhang et al., 2015).

The latest innovation in genetic engineering is the CRISPR-Cas9, the gene editing tool that allows researchers to cut DNA and paste in their chosen genetic material, creating genetically modified organisms. With other versions of CRISPR, scientists can manipulate genes in more precise ways, such as adding a new segment of DNA or editing single DNA letters (Moon et al., 2019). Scientists have also used CRISPR to detect specific targets, such as DNA from cancer-causing viruses and RNA from cancer cells. Scientists study CRISPR for many conditions, including high cholesterol, HIV, and Huntington’s disease. First and foremost, no federal legislation bans protocols or places restrictions on experiments that manipulate human DNA (Moon et al., 2019). Therefore, CRISPR is legal in the US. The FDA CRISPR regulating these trials significantly impacts diagnostics and therapeutics, allowing medicine to become more personalized (Memi et al., 2018). She said that treatments for cancer and blood disorders are furthest along because of how CRISPR is performed. “The most tested medical applications of CRISPR have been for cancer (Memi et al., 2018).

Some of the controversial potential dangers of CRISPR include a lab experiment to fix defective DNA in human embryos, which demonstrates potential errors with genealogical editing and why leading scientists say it is too unsafe to try (Moon et al., 2019). In more than half of the cases, the editing caused unintended changes, such as the loss of an entire chromosome or big chunks (Moon et al., 2019). His adverse effects may include the double-strand DNA breaks introduced during CRISPR editing, which could result in chromothripsis, a highly damaging form of genomic rearrangement resulting from the shattering of individual chromosomes, and the subsequent rejoining of the pieces in a random order (Moon et al., 2019). With the rapid application of CRISPR/Cas in clinical research, it is essential to consider the ethical implications of such advances (Memi et al., 2018). Pertinent issues include accessibility and cost, the need for controlled clinical trials with an excellent review, and policies for compassionate use. CRISPR is an ethical game-changer essentially because it changes the debate landscape. It reduces specific ethical concerns while significantly heightening others (Memi et al., 2018).

References

Memi, F., Ntokou, A., & Papangeli, I. (2018, December). CRISPR/Cas9 gene-editing: Research technologies, clinical applications and ethical considerations. In Seminars in perinatology (Vol. 42, No. 8, pp. 487-500). WB Saunders.

Moon, S. B., Kim, D. Y., Ko, J. H., & Kim, Y. S. (2019). Recent advances in the CRISPR genome editing tool set. Experimental & molecular medicine, 51(11), 1-11.

Zhang, B., Sun, Q., & Li, H. (2015). Advances in genetic modification technologies. Sheng wu Gong Cheng xue bao= Chinese Journal of Biotechnology, 31(8), 1162-1174.

A Sample Answer 3 For the Assignment: DNP-810 Topic 8 DQ 1

Title:  DNP-810 Topic 8 DQ 1

In this week’s discussion, you had some valid points regarding the use and implications of CRISPR or germ line genome editing. On one hand, it has helped to make amazing advances for people suffering from chronic illnesses or life-threatening cancers. On the other hand, there can be significant risks if this science is not carefully regulated or monitored. I felt nervous when you described the possibility of unintended gene errors such as the loss of chunks of DNA or even the loss of the entire chromosome. This has the potential to have a major impact on a person and society and it is hard to measure the potential consequences this could pose. In addition to risk for the individual and society, germ line editing has a potential risk for future generations Rubeis & Steger, 2018). This complex topic needs to be viewed through multiple lens, not solely from a biological perspective. It would be erroneous and irresponsible to not consider the moral and ethical consequences as well.

Reference

Rubeis, G. & Steger, F. (2018). Risks and benefits of human germline genome editing: an ethical analysis. Asian Bioethics Review, 10(2), 133-141. Doi: 10.1007/s41649-018-0056-x

A Sample Answer 4 For the Assignment: DNP-810 Topic 8 DQ 1

Title:  DNP-810 Topic 8 DQ 1

The story published within last 2 years, about genomic technology is, a study of an investigational gene therapy for sickle cell disease has found that a single dose restored blood cells to their normal shape and eliminated the most serious complication of the disease for at least three years in some patients.

Sickle cell disease is caused by mutations in the beta-globin gene, leading to the production of abnormal hemoglobin, the oxygen-carrying molecule in red blood cells. Normal red blood cells are shaped like donuts, but in sickle cell disease, the abnormal hemoglobin causes red blood cells to stiffen and adopt a spiky, sickle-like shape.  Sickle cell conditions are inherited from parents in much the same way as blood type, hair color and texture, eye color and other physical traits. The types of hemoglobin a person makes in the red blood cells depend upon what hemoglobin genes the person inherits from his or her parents. Like most genes, hemoglobin genes are inherited in two sets, one from each parent.

Four patients at NewYork-Presbyterian/Columbia University Irving Medical Center participated in the multicenter study, the first to report on such long-term outcomes of a sickle cell gene therapy. The single-dose therapy, tested on 35 adults and adolescents with sickle cell disease, essentially corrected the shape of the patient’s red blood cells, but also completely eliminated episodes of severe pain, caused when rigid, crescent-shaped red blood cells clump together and block blood vessels. The painful episodes often result in widespread organ damage. Such episodes are a frequent cause of emergency department visits and hospitalizations and lead to early death.

Care providers who manage patients with sickle cell disease (SCD) often face several ethical questions. Most prominent among these pertain to the importance of pain and its treatment. People with SCD suffer from a high incidence of social and behavioral health complications. Anxiety and depression have also been reported to be high in these patients. In addition, social and behavioral health complications can occur throughout life.

A nurse’s comprehensive pain assessment, noting location, intensity, and duration of the pain episode, is invaluable. Other nonpharmacologic therapies frequently used in SCD include cognitive behavioral therapy, biofeedback, prayer, relaxation techniques, acupuncture, hypnosis, and herbal therapies. Nurses should also assess patients for behavioral health complications to identify those who may benefit from social work, psychiatric, or case management referral. Patients should also be screened for depression, anxiety, and other social and behavioral determinants of health. When possible, nurses should refer patients with such complications to the social worker or case manager, who may be able to guide them in seeking extra support. A strong social support network is key to effective disease management and to a good quality of life in those with Sickle cell disease.

Tanabe, Paula PhD, RN; Spratling, Regena PhD, RN; Smith, Dana BSN; Grissom, Peyton BSN; Hulihan, Mary DrPH. CE: Understanding the Complications of Sickle Cell Disease. AJN, American Journal of Nursing: June 2019 – Volume 119 – Issue 6 – p 26-35 doi: 10.1097/01.NAJ.0000559779.40570.2c

Columbia University Irving Medical Center. (2021, December 13). Experimental gene therapy reverses sickle cell disease for years. ScienceDaily. Retrieved July 30, 2022 from http://www.sciencedaily.com/releases/2021/12/211213160126.htm

A Sample Answer 5 For the Assignment: DNP-810 Topic 8 DQ 1

Title:  DNP-810 Topic 8 DQ 1

Genetic technology advances have a significant clinical impact and signify that genetic testing perceptions must change. Genomic testing brings a more significant diagnostic opportunity for diagnosis alongside providing substantial predictions regarding future diagnoses. However, should therein reside an increased chance of uncertain or unexpected findings, many of which may impact multiple members of a person’s family (Zhang et al., 2015). The availability of treatment options regarding genetic technology is shifting and evolving, implicative of previously untreated disorders. Furthermore, the point of access to testing is changing with increasing provision direct to the consumer outside the formal healthcare setting (Zhang et al., 2015).

The latest innovation in genetic engineering is the CRISPR-Cas9, the gene editing tool that allows researchers to cut DNA and paste in their chosen genetic material, creating genetically modified organisms. With other versions of CRISPR, scientists can manipulate genes in more precise ways, such as adding a new segment of DNA or editing single DNA letters (Moon et al., 2019). Scientists have also used CRISPR to detect specific targets, such as DNA from cancer-causing viruses and RNA from cancer cells. Scientists study CRISPR for many conditions, including high cholesterol, HIV, and Huntington’s disease. First and foremost, no federal legislation bans protocols or places restrictions on experiments that manipulate human DNA (Moon et al., 2019). Therefore, CRISPR is legal in the US. The FDA CRISPR regulating these trials significantly impacts diagnostics and therapeutics, allowing medicine to become more personalized (Memi et al., 2018). She said that treatments for cancer and blood disorders are furthest along because of how CRISPR is performed. “The most tested medical applications of CRISPR have been for cancer (Memi et al., 2018).

Some of the controversial potential dangers of CRISPR include a lab experiment to fix defective DNA in human embryos, which demonstrates potential errors with genealogical editing and why leading scientists say it is too unsafe to try (Moon et al., 2019). In more than half of the cases, the editing caused unintended changes, such as the loss of an entire chromosome or big chunks (Moon et al., 2019). His adverse effects may include the double-strand DNA breaks introduced during CRISPR editing, which could result in chromothripsis, a highly damaging form of genomic rearrangement resulting from the shattering of individual chromosomes, and the subsequent rejoining of the pieces in a random order (Moon et al., 2019). With the rapid application of CRISPR/Cas in clinical research, it is essential to consider the ethical implications of such advances (Memi et al., 2018). Pertinent issues include accessibility and cost, the need for controlled clinical trials with an excellent review, and policies for compassionate use. CRISPR is an ethical game-changer essentially because it changes the debate landscape. It reduces specific ethical concerns while significantly heightening others (Memi et al., 2018).

References

Memi, F., Ntokou, A., & Papangeli, I. (2018, December). CRISPR/Cas9 gene-editing: Research technologies, clinical applications and ethical considerations. In Seminars in perinatology (Vol. 42, No. 8, pp. 487-500). WB Saunders.

Moon, S. B., Kim, D. Y., Ko, J. H., & Kim, Y. S. (2019). Recent advances in the CRISPR genome editing tool set. Experimental & molecular medicine, 51(11), 1-11.

Zhang, B., Sun, Q., & Li, H. (2015). Advances in genetic modification technologies. Sheng wu Gong Cheng xue bao= Chinese Journal of Biotechnology, 31(8), 1162-1174.